ABSTRACT
No abstract available.
Subject(s)
Adalimumab , Arthritis, Rheumatoid , Necrosis , Rheumatoid NoduleABSTRACT
PURPOSE: This retrospective study was done to investigate the mean platelet volume (MPV) level in patients with psoriasis vulgaris and its relationship with disease severity. MATERIALS AND METHODS: We undertook a cross-sectional study on 176 patients and 101 healthy controls to examine the association between MPV and psoriasis. Various clinical and laboratory parameters were analyzed and compared. RESULTS: Platelet distribution width and MPV were significantly higher in patients with psoriasis than controls. In addition, there was positive correlation between Psoriasis Area Severity Index (PASI) and MPV. When psoriasis patients were grouped into mild psoriasis (PASI or =10), the MPV of the latter group was significantly elevated. Nevertheless, patients with higher MPV level (MPV> or =10.4 fL) did not show higher PASI than lower MPV level (MPV<10.4 fL). MPV levels significantly decreased after improvements of psoriasis with various treatments. The variations of MPV and PASI also showed significant correlation. CONCLUSION: We have shown that MPV is increased in psoriasis patients and correlates with disease severity. Therefore, MPV levels may be considered as a marker of disease severity of psoriasis.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Blood Sedimentation , Cross-Sectional Studies , Mean Platelet Volume , Platelet Count , Psoriasis/blood , Retrospective Studies , Severity of Illness IndexABSTRACT
No abstract available.
Subject(s)
Humans , Histiocytoma, Benign Fibrous , Lymphoma, Large-Cell, Anaplastic , Lymphoma, Primary Cutaneous Anaplastic Large CellABSTRACT
PURPOSE: Dendritic cell (DC) vaccination for melanoma was introduced because melanoma carries distinct tumor-associated antigens. The purpose of this study was to investigate the efficacy and safety of DC vaccination for melanoma in Korea. MATERIALS AND METHODS: Five patients with stage IV and one with stage II were enrolled. Autologous monocyte-derived DCs (MoDCs) were cultured and pulsed with tumor-lysate, keyhole limpet hemocyanin, and cytokine cocktail for mature antigen-loaded DC. DC vaccination was repeated four times at 2-week intervals and 2-4x107 DC were injected each time. RESULTS: Reduced tumor volume was observed by PET-CT in three patients after DC vaccination. Delayed type hypersensitivity responses against tumor antigen were induced in five patients. Tumor antigen-specific IFN-gamma-producing peripheral blood mononuclear cells were detected with enzyme-linked immunosorbent spot in two patients. However, the overall clinical outcome showed disease progression in all patients. CONCLUSION: In this study, DC vaccination using tumor antigen-loaded, mature MoDCs led to tumor regression in individual melanoma patients. Further standardization of DC vaccination protocol is required to determine which parameters lead to better anti-tumor responses and clinical outcomes.
Subject(s)
Humans , Dendritic Cells/cytology , Enzyme-Linked Immunosorbent Assay , Flow Cytometry , Immunotherapy/methods , Melanoma/therapy , Monocytes/cytology , Treatment OutcomeABSTRACT
Cutaneous metastases from internal malignancies are, occurring in 0.5% to 9% of cases. Lung, breast, and colorectal cancers are common primary tumors that metastasize to the skin; cutaneous metastasis usually occurs on the chest wall and abdomen as asymptomatic nodular patterns. Esophageal cancer is not nearly as common as breast, lung, and colorectal cancers, and esophageal cancer rarely metastasizes to the skin. Cutaneous metastasis of esophageal cancer is rare and metastasis to the scalp is extremely rare. Only a few cases of cutaneous metastases of esophageal cancer have been reported in Korea. Most of the cases involved cutaneous metastases arising from esophageal squamous cell carcinoma; however, there have been several reports describing cutaneous metastases from esophageal adenocarcinomas. Herein, we describe a case of metastatic skin cancer that originated from esophageal adenocarcinoma.
Subject(s)
Abdomen , Adenocarcinoma , Breast , Colorectal Neoplasms , Esophageal Neoplasms , Esophagus , Korea , Lung , Neoplasm Metastasis , Scalp , Skin , Skin Neoplasms , Thoracic WallABSTRACT
BACKGROUND: Various allergens and irritants induced the production of reactive oxygen species (ROS) in the well-established mouse dendritic cell (DC) line XS106 and this production of ROS was inhibited by antioxidants. OBJECTIVE: To investigate the production and functions of ROS in mouse bone marrow-derived DCs (BM-DCs) by various haptens and irritants, we examined the production of ROS, the expression of surface molecules, and the production of interleukin-12 (IL-12) in mouse BM-DCs. METHODS: Six to eight-week-old female C57/BL6 mice were used in this study. Mouse BM-DCs were co-cultured with DNFB, DNCB, TNBS, hydroquinone, NiSO4, CoCl2, MnCl2, thimerosal, SDS, and BKC. The production of ROS and the expression of surface molecules (CD40, CD80, CD86, and MHC-II) were measured by flow cytometry in chemical-treated mouse BM-DCs. In addition, the cells were pretreated with antioxidants to determine whether the production of ROS can be inhibited. The production of IL-12 was also measured in DNCB and SDS-treated mouse BM-DCs using ELISA. Results: The production of ROS in mouse BM-DCs was induced by various allergens, including DNFB, DNCB, TNBS, hydroquinone, MnCl2 and irritants like SDS, BKC. The expression of surface molecules was induced by various chemicals and NiSO4 was the most potent inducer of surface molecules in mouse BM-DCs. The production of ROS in DNCB and SDS-treated mouse BM-DCs was partially inhibited by diphenylene iodonium, but not by rotenone, vitamin E, allopurinol, glutathione. The production of IL-12 was not detected in DNCB and SDS-treated mouse BM-DCs. CONCLUSION: The production of ROS was induced in mouse BM-DCs by various allergens and irritants. The expression of surface molecules was also induced by various chemicals. The production of ROS was partially inhibited by DPI. The production of IL-12 was not detected.
Subject(s)
Animals , Female , Humans , Mice , Allergens , Allopurinol , Antioxidants , Chlorides , Dendritic Cells , Dinitrochlorobenzene , Dinitrofluorobenzene , Flow Cytometry , Glutathione , Haptens , Hydroquinones , Interleukin-12 , Irritants , Manganese Compounds , Onium Compounds , Reactive Oxygen Species , Rotenone , Thimerosal , Vitamin E , VitaminsABSTRACT
Tumor necrosis factor-alpha antagonists include monoclonal antibodies, infliximab, adalimumab, etanercept and golimumab. Clinical trials of these agents have shown that they are remarkably effective for psoriasis, but cutaneous adverse reactions of these agents including paradoxical aggravation of psoriasiform eruption have been also reported. We present a case of psoriasiform eruption triggered by golimumab therapy in a patient with rheumatoid arthritis. A 53-year-old woman presented with a skin lesion on the sole. She had been treated by golimumab every 4 weeks for rheumatoid arthritis from September 2006. 16 weeks after the treatment, she developed a erythematous and scaly patch on the sole. She had a history of palmoplantar pustulosis, but the skin lesions had not appeared for a long time, recurring when she started golimumab treatment. The skin lesion improved with topical steroid treatment, but as golimumab was re-administrated, the skin lesion exacerbated.
Subject(s)
Female , Humans , Middle Aged , Antibodies, Monoclonal , Antibodies, Monoclonal, Humanized , Arthritis, Rheumatoid , Immunoglobulin G , Psoriasis , Receptors, Tumor Necrosis Factor , Skin , Tumor Necrosis Factor-alpha , Adalimumab , Infliximab , EtanerceptABSTRACT
The combination of interferon alpha with ribavirin is currently recommended in the treatment of hepatitis C virus (HCV) infection. Commonly reported cutaneous reactions include localized reactions such as injection site inflammation and necrosis and worsening of other skin disorders, including psoriasis, lichen planus, vitiligo, or systemic lupus erythematosus. However, generalized eczematous reactions have been reported to occur uncommonly in patients treated with interferon and ribavirin, however such a case has not been described in the Korean literature. Herein, we describe a 49-year old female showing generalized eczema-like eruption after treatment of interferon alpha-2b and ribavirin for chronic HCV infection.
Subject(s)
Female , Humans , Hepacivirus , Hepatitis C, Chronic , Hepatitis, Chronic , Inflammation , Interferon-alpha , Interferons , Lichen Planus , Lupus Erythematosus, Systemic , Necrosis , Psoriasis , Ribavirin , Skin , VitiligoABSTRACT
Eosinophilic cellulitis is a rare, recurrent dermatosis which was first described by Wells in 1971. The etiology and pathogenesis of eosinophilic cellulitis are currently unknown, but a type IV hypersensitivity to various antigens followed by vascular damage seems to play a role in the pathogenesis of eosinophilic cellulitis. Most cases of eosinophilic cellulitis occur in adults. Only 29 cases have been reported in children. Generally, pediatric cases are recurrent but show good response to systemic steroids. We present a case of eosinophilic cellulitis in an 8-year-old boy. Who presented with acute onset of erythematous plaques on both thighs. These lesions were pruritic but not painful. A skin biopsy specimen showed dense mixed inflammatory infiltrations that consisted mostly of eosinophils, lymphocytes and histiocytes. Flame figures surrounded by eosinophils and histocytes and foci of degenerated collagen bundles were observed in the dermis. The lesions resolved rapidly after the initiation of oral steroid therapy. After 6 months, the patient has not experienced recurrence of the disease.
Subject(s)
Adult , Child , Humans , Male , Biopsy , Cellulitis , Collagen , Dermis , Eosinophils , Histiocytes , Hypersensitivity, Delayed , Lymphocytes , Recurrence , Skin , Skin Diseases , Steroids , ThighABSTRACT
Epidermolytic acanthoma is an uncommon benign tumor characterized histologically by epidermolytic hyperkeratosis. Clinically, the tumor resembles a verruca or seborrheic keratosis and may occur in either isolated or disseminated forms. Herein, we present a case of a 46-year-old male who developed multiple seborrheic keratosis or verruca like papules on his trunk which showed epidermolytic hyperkeratosis upon microscopic examination. Following clinical and histological findings, the patient was diagnosed as having disseminated epidermolytic acanthoma.
Subject(s)
Humans , Male , Middle Aged , Acanthoma , Hyperkeratosis, Epidermolytic , Keratosis, Seborrheic , WartsABSTRACT
BACKGROUND: Oral lichen planus (OLP) is a relatively common chronic inflammatory oral mucosal disease of unknown cause. Oral lesions in OLP are chronic, rarely undergo spontaneous remission, are potentially premalignant and are often a source of morbidity. OBJECTIVE: The purpose of our investigation was to describe the clinical characteristics of 35 patients with biopsy- proven OLP. METHODS: We reviewed the medical records and clinical photographs of 35 patients who had been diagnosed with OLP during the last 5 years, from January 2001 to March 2006. We identified average age of onset, gender distribution, presence of family history, clinical types, location of the oral lesion, symptoms, associated dermatologic and systemic disease and treatment modalities. RESULTS: Of the 35 patients, 65.7% were women and 34.3% men. The average age of onset for men was 41.2 years and for women was 52.4 years (overall average age of onset was 48.5 years). Only 5 patients had a family history of OLP, which had not been proven by histologic examination. Of the 35 OLP patients, the reticular type was found in 45.7%, the erythematous type in 31.4% and erosive type in 22.9% of patients. The most common site of oral lesions was the buccal mucosa, which was found in 57.1% of the patients. The lips were the second most commonly involved site at 48.6%, then the tongue at 8.6% and gingiva at 5.7%. Except for the 4 asymptomatic patients, the rest of the patients complained of various symptoms such as a pain, a burning sensation, pruritus and irritation. Many cutaneous and systemic diseases were associated with OLP patients. 3 patients had concomitant cutaneous lichen planus. Only 1 patient was found to be infected with hepatitis C virus. Various treatments had been tried by all patients. Oral squamous cell carcinoma developed in 1 patient at sites previously diagnosed by biopsy as OLP. CONCLUSION: This is the first clinical study of OLP patients in the Korean dermatologic literature. The clinical features of patients in this survey share many similarities with those reported previously, but showed some differences too. The clinical findings of OLP should be evaluated in much larger groups of patients and more experimental investigations should be conducted to find out exact pathogenesis and effective treatments for OLP.
Subject(s)
Female , Humans , Male , Age of Onset , Biopsy , Burns , Carcinoma, Squamous Cell , Gingiva , Hepacivirus , Lichen Planus , Lichen Planus, Oral , Lip , Medical Records , Mouth Mucosa , Pruritus , Remission, Spontaneous , Sensation , TongueABSTRACT
Radiation recall dermatitis is the development of an inflammatory reaction in the previously irradiated area, precipitated by the administration of certain drugs. A 54-year-old man was diagnosed with follicular lymphoma, grade 3 and stage 3. Cancer recurred two years after complete remission obtained by chemotherapy and radiotherapy. Therefore, he was again treated with fludarabine and mitoxantrone for five cycles, then underwent an allogeneic peripheral blood stem cell transplantation (PBSCT). The patient started to receive methotrexate the day after PBSCT. On the day of the first methotrexate administration, the patient developed erythematous erosions with pruritus and severe pain in the previously irradiated area. The skin lesion resolved almost completely after dressing with topical antibiotics and wet dressing with 0.3% aluminium solution for 2 weeks. We report a case of radiation recall dermatitis in a patient with follicular lymphoma that occurred after receiving methotrexate.
Subject(s)
Humans , Middle Aged , Anti-Bacterial Agents , Bandages , Drug Therapy , Lymphoma, Follicular , Methotrexate , Mitoxantrone , Peripheral Blood Stem Cell Transplantation , Pruritus , Radiodermatitis , Radiotherapy , SkinABSTRACT
Dermatofibroma is a common benign fibrohistiocytic tumor that occurs anywhere on the body surface, with a propensity for the extremities, usually the lower legs. A 31-year-old male presented with a skin-colored nodule measured 0.5 cm in diameter on the sole of hisfoot. A biopsy specimen revealed a poorly defined, nonencapsulated, nodular tumor composed of collagen bundles, fibroblasts and histiocytes, which were consistent with dermatofibroma. Herein we report a case of dermatofibroma on the sole.
Subject(s)
Adult , Humans , Male , Biopsy , Collagen , Extremities , Fibroblasts , Histiocytes , Histiocytoma, Benign Fibrous , LegABSTRACT
Subungual exostosis is a benign, acquired tumor of cartilaginous bone which occurs beneath the nail of the distal phalanx, and can often lead to displacement and deformity of the overlying nail. Complete surgical excision is a curative treatment for subungual exostosis. Since there have been no case reports of complete surgical removal of subungual exostosis in the Korean dermatologic literature, we report four cases of subungual exostosis that were successfully treated through complete excision or excision in combination with additional curettage.